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Anna Chernova
V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Russian FederationPresentation Title:
Prognostic model for the development of cardiomyopathies based on genetic predictors
Abstract
Aim: To develop a prognostic model for the development of primary and secondary cardiomyopathy based on genetic predictors.
Material and methods: The study included 221 patients with cardiomyopathy. The mean age of the participants was 55,30±9,69 years, with the age range from 20 to 77 years. The following two groups of patients were determined: the first group (n=111) with idiopathic dilated cardiomyopathy and the second group (n=110) with ischemic myocardial dilation.
Results: The performed multivariate analysis using the stepwise selection method showed a significant effect of the following predictors at the third step: AG/GG allelic variant of the SCN5A gene (rs1805124), 6a/6a allelic variant of the MMP3 gene (rs35068180) and the patient's age. The performed multivariate analysis using the stepwise selection showed a significant effect of the following predictors: AG/GG allelic variant of the CTLA4 gene (rs231775), AA and AG allelic variants of the SCN5A gene (rs1805124).
Biography
Anna A. Chernova, M.D., Ph.D., Dr. Med. Sci. Total number papers is > 100, incl. >50 papers in Russian and international peer-reviewed journals. 2013.9 - till now Professor of Department of Internal diseases Krasnoyarsk State Medical University named after Prof. V.F.Voino-Yasenetsky, Russia. 2015.9 – 9.2020 Head of Russian-Italian Laboratory of Medical Genetics (former Laboratory, 2014-2016), Krasnoyarsk State Medical University named after Prof. V.F.Voino-Yasenetsky, Russia 2015.4-4.2021Chairman of the Working Group of Young Cardiologist Russian Society of Cardiology, Russia 2017.11 - 06.2021 Editor of the international journal «Medical University» 2020.04 – till now Head of the Science and Innovation Department of the FSFI FSRCC FMBA of Russia
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