Despite the changed severity of the COVID-19 infection, vaccination issues remain relevant, considering the high number of newly infected patients in 2025. 

Aim:

To study was to assess the duration and severity of colitis in vaccinated and unvaccinated patients with SARS-Covid-19.

Materials and methods:

There were analysed 201 medical records of patients with COVID-19 who were hospitalized from 2021 to 2022. The diagnosis COVID-19 infection was made in the presence of a positive result from a laboratory study for SARS-COV-2 RNA using a PCR test for coronavirus infection. All patients were divided into 2 groups: vaccinated with 'Gam-COVID-Vak' and unvaccinated patients. In the group of vaccinated COVID-19 patients, there were 23 patients (22.77%) with colitis, in the unvaccinated group - 27 (27%) patients. The diagnosis colitis was made based on clinical and laboratory data, as well as a negative test for Cl. difficile.

Results:

Vaccinated patients were more comorbid. They had a significantly higher prevalence of chronic heart failure, and respiratory diseases, p<0.05. Unvaccinated patients had a significantly higher prevalence of hypertension, p<0.05. In the subgroup unvaccinated colitis patients, there was a tendency towards a more pronounced increase in leukocyte levels compared to the subgroup vaccinated colitis patients: 18.7 (8.2; 29.2) * 10^9 g/l and 10.3 (6.1; 14.5) * 10^9 g/l, respectively (p>0.05). The level of CRP in the serum unvaccinated colitis patients also showed a tendency towards a higher level than in the subgroup vaccinated colitis patients: 126.4 (48.1; 204.6) mg/l and 108.8 (34.3; 183.2) mg/l, respectively (p>0.05). The longest duration of hospitalization was recorded in the subgroup unvaccinated colitis patients from COVID-19 infection (20 (11; 29) days).

Conclusion:

Despite the higher frequency of chronic diseases in the medical history of the group vaccinated patients against COVID-19 compared to the group unvaccinated patients, there were no statistically significant differences in mortality rates recorded. In cases of colitis, it was most severe in the subgroup unvaccinated COVID-19 patients.

TBA